Objective: Doxorubicin has proven to be partly efficacious in treating glioblastoma multiforme. However, the conventional formulation of doxorubicin has not been used clinically, due to poor penetration of the blood-brain barrier.To overcome these obstacles, authors compared the use of Specific conjugate particle doxorubicin (Group 1), a proven efficacious agent with advanced technical drug, and pegylated liposomal Doxorubicin (Group 2) in a randomized prospective Phase III trial involving patients with recurrent high-grade glioma.
Download Pdf